The glucuronidation pathway is one of the most important Phase II
conjugation pathways in the liver for the clearing of toxins and steroid
hormones. Calcium D-Glucarate helps support the natural excretion of
toxins that have been conjugated via the glucuronidation pathway.
A major pathway of Phase II activity in the liver is the conjugation of
toxins with glucuronide (a sugar) - the glucuronidation pathway. The
enzyme beta-glucuronidase, when produced by gut bacteria, can
de-conjugate the glucuronide-toxin complex, freeing toxic substances
in the gut, which may cause damage locally or be reabsorbed
systemically. Calcium D-Glucarate has been shown to inhibit the
activity of beta-glucuronidase.
• Calcium D-Glucarate is also a source of absorbable calcium.