The glucuronidation pathway is one of the most important Phase II conjugation pathways in the liver for the clearing of toxins and steroid hormones. Calcium D-Glucarate helps support the natural excretion of toxins that have been conjugated via the glucuronidation pathway. A major pathway of Phase II activity in the liver is the conjugation of toxins with glucuronide (a sugar) - the glucuronidation pathway. The enzyme beta-glucuronidase, when produced by gut bacteria, can de-conjugate the glucuronide-toxin complex, freeing toxic substances in the gut, which may cause damage locally or be reabsorbed systemically. Calcium D-Glucarate has been shown to inhibit the activity of beta-glucuronidase. • Calcium D-Glucarate is also a source of absorbable calcium.